A new meaning to “go with your gut.”

Prebiotics vs. probiotics: what’s the difference?

Learn about the bacteria that’s keeping you going and how to support them.

Probiotics are live microorganisms — often called “good bacteria” — that help balance your gut microbiota and are naturally in fermented foods like yogurt, sauerkraut, kimchi, and kefir.

When your gut is disrupted — by stress, antibiotics, or processed food—probiotics can help restore balance by replenishing helpful bacteria. Meta-analyses show probiotics may modestly reduce symptoms of depression and anxiety, particularly in clinical populations, and may also boost brain-derived neurotrophic factor (BDNF) while reducing inflammation markers like C-reactive protein (CRP).[1]
Probiotics help with supporting digestion and nutrient absorption, strengthening immune defenses and balancing mood and reducing inflammation.

If probiotics are the tenants in your gut, think of prebiotics as their food. These are types of dietary fiber — like inulin, fructooligosaccharides (FOS), and galactooligosaccharides (GOS) — that resist digestion in the upper GI tract and ferment in the colon, feeding beneficial bacteria, aka probiotics.[2][3]

Prebiotic fibers support long-term gut health, your immune system, as well as regulate blood sugar and promote fullness, making them a wellness staple.

The dynamic duo for your gut

Probiotics add helpful strains to your gut and prebiotics feed them. Together, they’re known as synbiotics—a synergistic combo that research suggests may outperform either one used alone. Studies link synbiotics with better digestion, reduced inflammation, and improved mood and mental health[1].

For most people, a diet rich in fiber-filled plants and fermented foods offers great support. But if you’re on the go or can’t get around to get your fruits, veggies and grains in, supplementing with a synbiotic blend can help fill in the gaps.

The Bottom Line

Add in pre- and probiotics to your supplement routine for maximum gut benefits.

Gut health equals whole-body health — and prebiotics and probiotics are two sides of the same coin. Together, they support digestion, mood, immunity, and energy. Whether through food or thoughtfully formulated supplements, adding both to your daily routine is a simple, powerful act of self-care.

Sources

  1. Rahimnia, R., et al. “Strain-Specific Effects of Probiotics on Depression and Anxiety: A Meta-Analysis.” Gut Pathogens, 2024. https://pubmed.ncbi.nlm.nih.gov/39245752/
  2. Kaewarsar E, Chaiyasut C, Lailerd N, Makhamrueang N, Peerajan S, Sirilun S. Optimization of Mixed Inulin, Fructooligosaccharides, and Galactooligosaccharides as Prebiotics for Stimulation of Probiotics Growth and Function. Foods. 2023 Apr 9;12(8):1591. doi: 10.3390/foods12081591. PMID: 37107386; PMCID: PMC10137966. https://pmc.ncbi.nlm.nih.gov/articles/PMC10137966/
  3. Guarino MPL, Altomare A, Emerenziani S, Di Rosa C, Ribolsi M, Balestrieri P, Iovino P, Rocchi G, Cicala M. Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults. Nutrients. 2020 Apr 9;12(4):1037. doi: 10.3390/nu12041037. PMID: 32283802; PMCID: PMC7231265. https://pmc.ncbi.nlm.nih.gov/articles/PMC7231265/